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Description: Builds a deep learning network to classify the cancer type from patient Somatic SNPs.
DESCRIPTION:

Builds a deep learning network to classify the cancer type from patient Somatic SNPs.

IMPACT: Offers a means for classifying sparse data.
INPUT DATA FORMAT: Tabular
LEVEL OF DOCUMENTATION: Minimal
Description: Classifies tumor type; augments existing data quality control methods.
DESCRIPTION:

Classifies tumor type; augments existing data quality control methods.

IMPACT: Offers a 1D-convolutional network for classifying RNA-Seq gene expression profiles into normal or tumor tissue categories.
INPUT DATA TYPE: Gene Expression
INPUT DATA FORMAT: Tabular
LEVEL OF DOCUMENTATION: Minimal
Project: IMPROVE
Description: This is a community model for drug response prediction curated as part of the IMPROVE project.
DESCRIPTION:

This is a community model for drug response prediction curated as part of the IMPROVE project.

IMPACT: Enables prediction of drug response with drug and cancer features.
INPUT DATA TYPE: Gene Expression, Drug Fingerprints, Drug SMILES
INPUT DATA FORMAT: Tabular
LEVEL OF DOCUMENTATION: Moderate
Project: ATOM
Description: The QMugs HOMO-LUMO Gap Prediction Model enables users to predict HOMO-LUMO energy gap.
DESCRIPTION:

The QMugs HOMO-LUMO Gap Prediction Model enables users to predict HOMO-LUMO energy gap.

IMPACT: The QMugs HOMO-LUMO Gap Prediction Model enables users to predict HOMO-LUMO energy gaps, a molecular property that provides information about the stability and reactivity of a molecule. Molecular stability is a necessary consideration in drug design that impacts pharmaceutical reactivity and interactions in vivo, affecting the viability of cancer treatments.
INPUT DATA FORMAT: Unspecified
LEVEL OF DOCUMENTATION: Minimal
Project: MOSSAIC
Description: Generates synthetic biomedical text of desired clinical context.
DESCRIPTION:

Generates synthetic biomedical text of desired clinical context.

IMPACT: Creates examples of unstructured text with a specific label from a given corpus that can be used for training machine learning or deep learning models on clinical text. Labeled data is quite challenging to come by, specifically for patient data, for deep text comprehension applications.
INPUT DATA FORMAT: Unspecified
LEVEL OF DOCUMENTATION: Minimal
Project: ATOM
Description: Machine-learning models made to study safety parameters using large datasets, which include raw data from DTC, ChEMBL, and ExCAPE-DB databases, as well as the Union train/test dataset. The corresponding Union models are trained on each Union training set with an open-source software called the ATOM Modeling PipeLine (AMPL).
DESCRIPTION:

Machine-learning models made to study safety parameters using large datasets, which include raw data from DTC, ChEMBL, and ExCAPE-DB databases, as well as the Union train/test dataset. The corresponding Union models are trained on each Union training set with an open-source software called the ATOM Modeling PipeLine (AMPL).

IMPACT: Enables disease target identification.
INPUT DATA FORMAT: Unspecified
LEVEL OF DOCUMENTATION: Minimal
Description: Shows how to train and use a neural network model to predict tumor dose response.
DESCRIPTION:

Shows how to train and use a neural network model to predict tumor dose response.

IMPACT: Enables prediction of growth percentage of a cell line treated with a new drug.
INPUT DATA TYPE: Drug Molecular Descriptors, Drug Concentrations, Gene Expression
INPUT DATA FORMAT: Tabular
LEVEL OF DOCUMENTATION: Minimal
Description: Allows classification of tumor type based on sequence data; these augment existing data quality control methods.
DESCRIPTION:

Allows classification of tumor type based on sequence data; these augment existing data quality control methods.

IMPACT: Augments existing data quality control methods.
INPUT DATA TYPE: Gene Expression
INPUT DATA FORMAT: Tabular
LEVEL OF DOCUMENTATION: Minimal
Project: IMPROVE
Description: This is a community model for drug response prediction curated as part of the IMPROVE project.
DESCRIPTION:

This is a community model for drug response prediction curated as part of the IMPROVE project.

IMPACT: Enables prediction of drug response with drug and cancer features.
INPUT DATA TYPE: Gene Expression, Drug SMILES
INPUT DATA FORMAT: Tabular
LEVEL OF DOCUMENTATION: Moderate
Description: Allows predictive classification of primary tumor type based on gene expression data.
DESCRIPTION:

Allows predictive classification of primary tumor type based on gene expression data.

IMPACT: Augments existing data quality control methods. Allows users to make predictions on previously unseen data.
INPUT DATA TYPE: Gene Expression
INPUT DATA FORMAT: Tabular
LEVEL OF DOCUMENTATION: Moderate